Having a mastectomy?

Concerned about long-term pain?

Having a mastectomy?
Concerned about long-term pain?

Join us as we learn how to best prevent chronic pain after a mastectomy

Join us as we learn how to best prevent chronic pain after a mastectomy

ABOUT THE
KALPAS STUDY

KALPAS is a nationwide research study for women having a mastectomy. The study is looking at whether ketamine helps prevent long-term (chronic) pain after surgery.

ABOUT THE
KALPAS STUDY

KALPAS is a nationwide research study for women having a mastectomy. The study is looking at whether ketamine helps prevent long-term (chronic) pain after surgery.

Ketamine:

• is a non-opioid, FDA-approved drug

• can help reduce pain and depression

• has been safely used for medical care over the last 50 years

Long-term pain after a mastectomy is very common. Up to 6 out of every 10 women continue to have pain more than 3 months after surgery.

Ketamine:

• is a non-opioid, FDA-approved drug

• can help reduce pain and depression

• has been safely used for medical care over the last 50 years

Long-term pain after a mastectomy is very common. Up to 6 out of every 10 women continue to have pain more than 3 months after surgery.

WHO CAN JOIN

You may be able to join if you are:

• a woman

• at least 18 years of age or older

• having a mastectomy to prevent or treat possible cancer

Taking part in the KALPAS Study is up to you. If you join, you can leave the study at any time.

WHO CAN JOIN

You may be able to join if you are:

• a woman

• at least 18 years of age or older

• having a mastectomy to prevent or treat possible cancer

Taking part in the KALPAS Study is up to you. If you join, you can leave the study at any time.

WHAT TO EXPECT

First, we will ask you a few brief questions about yourself to see if the study is a good fit for you.

If you join, you will be in the study for one year. You will have an equal opportunity to be assigned
to 1 of 3 groups. This is the best way to see if ketamine helps prevent chronic pain.

Group 1:

will receive ketamine during and right after surgery

Group 2:

will receive ketamine right after the surgery

Group 3:

will receive saline (placebo) during and after the surgery

No matter which group you are in, the rest of your mastectomy – including surgery, medication
to sleep during surgery, and care after the surgery – will follow normal medical procedures.

Duration

1 year

Duration

1 year

Number of visits

6 follow-ups during the 1 year of the study:

    • 1 day

    • 7 days

    • 1 month

    • 3 months

    • 6 months

    • 12 months

All follow-up activities can be done from your own home and will take an estimated 10-30 minutes to complete.

Number of visits

6 follow-ups during the 1 year of the study:

    • 1 day

    • 7 days

    • 1 month

    • 3 months

    • 6 months

    • 12 months

All follow-up activities can be done from your own home and will take an estimated 10-30 minutes to complete.

Study Follow-Up Activities

You will answer questions about
yourself including your pain, mood, and
physical activity.

Any surveys that are part of the follow-up can be completed online or over the phone.

Study Follow-Up Activities

You will answer questions about
yourself including your pain, mood, and
physical activity.

Any surveys that are part of the follow-up can be completed online or over the phone.

Medication

Ketamine or saline (placebo) based on which group you are assigned to.

Medication

Ketamine or saline (placebo) based on which group you are assigned to.

Study Costs

There will be no study-related costs to you.

Study Costs

There will be no study-related costs to you.

Compensation

You will be compensated up to $150 for all the parts of the follow-up you complete.

Compensation

You will be compensated up to $150 for all the parts of the follow-up you complete.

REASONS TO JOIN

 

  • You may have less pain after your surgery, as well as long term.

  • It may lower your need for taking opioids.

  • It could also improve your mood and help you feel less anxious.

  • Your participation may help other women having mastectomies in the future.

REASONS TO JOIN

 

  • You may have less pain after your surgery, as well as long term.

  • It may lower your need for taking opioids.

  • It could also improve your mood and help you feel less anxious.

  • Your participation may help other women having mastectomies in the future.

PARTICIPATING SITES

CONTACT US

To find more about the KALPAS study, please contact the study team closest to you.

Massachusetts

Brigham and Women’s Hospital – Harvard University
mcornelius@bwh.harvard.edu
617-732-9463

Missouri

Washington University Medical Center
lindayun@wustl.edu
314-273-2240

New York

NYU Langone Health Hospitals
(Tisch/Kimmel, Brooklyn and Long Island)
kalpas@nyulangone.org
212- 263 -1538

NYC Health + Hospitals / Bellevue
deborah.ok@nyulangone.org
212-263-5072

Memorial Sloan Kettering Cancer Center
lochanss@mskcc.org
646-735-8059

NY Presbyterian Columbia
University Irving Medical Center
si2271@cumc.columbia.edu
212-342-3681

Montefiore Medical Center –
Albert Einstein College of Medicine
cjoco@montefiore.org
646-942-0519]

Pennsylvania

University of Pittsburgh Magee – Women’s Hospital
altamiranov3@upmc.edu

Texas

University of Texas Southwestern Medical Center
emily.melikman@utsouthwestern.edu
214-645-7011

Washington

University of Washington Medical Center
lyflint@uw.edu
206-543-7817

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